P101
Sigma
2-Phenylaminoadenosine
>97%, solid
| Synonym: | CV-1808 |
| Linear Formula: | C16H18N6O4 |
| Molecular Weight: | 358.35 |
| MDL number: | MFCD00055119 |
| PubChem Substance ID: | 24277727 |
Description
| Biochem/physiol Actions | Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes. |
| Reconstitution | Solutions should be freshly prepared. |
Properties
| assay | >97% |
| form | solid |
| color | white |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL |
| H2O: insoluble | |
| absolute ethanol: slightly soluble | |
| ethanol: water (1:1): soluble | |
| hot methanol: soluble | |
| Gene Information | human ... ADORA2A(135), ADORA2B(136) |
| rat ... Adora1(29290), Adora2a(25369) | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Taylor, et al., Interaction of 2-phenylaminoadenosine (CV 1808) with adenosine systems in rat tissues. Eur. J. Pharmacol. 85, 335-338, (1982) Abstract |
| Wu, et al., Further studies on the inhibition of adenosine uptake into rat brain synaptosomes by adenosine derivatives and methylxanthines. Gen. Pharmacol. 15, 251-254, (1984) Abstract | |
| Phillis, et al., Behavioral characteristics of centrally administered adenosine analogs. Pharmacol. Biochem. Behav. 24, 263-270, (1986) Abstract |
